PfEMP1 variants identified in children with severe malaria!

I don’t have time to spend on this but I can’t wait to read it!  You can’t build drugs to target malaria in large part because of the presence of “var” genes. The “var” stands for variable and it’s exactly what you’d think. Messed up, mutated, switched around and hard to target because of this.Continue reading “PfEMP1 variants identified in children with severe malaria!”

Bioinformazing — YPIC 2018 Results

The results of (Young Proteomics Investigators Challenge) YPIC 2018 are out and — this is just amazing all around. I rambled about last year’s a little here.  2018 was a step up in complexity from all sides —  How crazy is that?  One — that this challenge is possible to set up at all!?!  AndContinue reading “Bioinformazing — YPIC 2018 Results”

Selenoproteins identified and quantified with TMT proteomics!

I sometimes think that my most positive attribute is that I have no problem accepting that I’m a moron. I got one sentence into this new-ish JASMS paper and was like — “yup, I’m still totally dumb.” I quote: “The essential trace element selenium (Se) functions through it’s incorporation as the 21st amino acid, selenocysteineContinue reading “Selenoproteins identified and quantified with TMT proteomics!”

Proteome Discovererer 2.4 Scripting nodes!!

Yes — Perseus has basically always been able to interface with external code and programs and has ugly little icons to link all this stuff together — but Proteome Discoverer never has without being in the ultra special developer’s club! TADAAAAA!!!!  The Proteome Discovererererererererer  2.4 Scripting nodes! It’s SO EASY THAT I CAN DO IT!Continue reading “Proteome Discovererer 2.4 Scripting nodes!!”

Maximizing Ion Trap MS/MS Acquisitions! (Get 12% more IDs out of any system?!?!)

I took a semester off from school in undergrad. Up to that point my priorities were running around in a costume (I was my school’s mascot), dancing and tumbling poorly in said costume at basketball games I got into for free and had the best seat possible for (! no seat!) and going to aContinue reading “Maximizing Ion Trap MS/MS Acquisitions! (Get 12% more IDs out of any system?!?!)”

Stalking e botte alla fidanzata, i carabinieri arrestano il ballerino Andy Milo

La donna soccorsa in casa e medicata al Sant’Anna, poi denuncia di essere vittima da diversi mesi di maltrattamenti da parte del cantante padovano finito su ‘Striscia’ Copparo. Violenze fisiche, psicologiche e minacce alla fidanzata che voleva lasciarlo. Sarebbero durate per mesi, fino alla notte tra il 10 e l’11 settembre quando lei, dopo essereContinue reading “Stalking e botte alla fidanzata, i carabinieri arrestano il ballerino Andy Milo”

‘Operation Illogic’ takes down alleged multimillion-dollar counterfeit e-cigarette ring

A father and his two sons have been charged in an alleged multimillion-dollar counterfeit vaping product ring. Investigators say a lengthy investigation led to the arrests of Asgar Ali, and his sons Moosa and Zar, of East Meadow. They say more than 10,000 pieces of counterfeit electronic cigarettes, e-cig refills and vape pens were seizedContinue reading “‘Operation Illogic’ takes down alleged multimillion-dollar counterfeit e-cigarette ring”

Time for Fiscal Rules?

Should governments set rules to constrain the size of government borrowing on an annual basis or government debt accumulated over time? Pierre Yared discusses the question in “Rising Government Debt: Causes and Solutions for a Decades-Old Trend,” in the Spring 2019 issue of the Journal of Economic Perspectives. There’s really no economic case to beContinue reading “Time for Fiscal Rules?”

Origins of "Microeconomics" and "Macroeconomics"

Economists have written about topics that we would now classify under the headings of “microeocnomics” or “macroeconomics” for centuries. But the terms themselves are much more recent, emerging only in the early 1940s. For background, I turn to the entry on “Microeconomics” by Hal R. Varian published in The New Palgrave: A Dictionary of Economics,Continue reading “Origins of "Microeconomics" and "Macroeconomics"”

Strengthening Automatic Stabilizers

For economists, “automatic stabilizers” refers to how tax and spending policies adjust without any additional legislative policy or change during economic upturns and downturns–and do so in a way that tends to stabilize the economy. For example, in an economic downturn, a standard macroeconomic prescription is to stimulate the economy with lower taxes and higherContinue reading “Strengthening Automatic Stabilizers”

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